Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194091 | 0.91 | CYP3A4 (0.60) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14198428 | 0.89 | CYP3A4 (0.48) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14194082 | 0.89 | CYP3A4 (0.48) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14197568 | 0.88 | CYP2C19 (0.48) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14198421 | 0.87 | CSF1R (0.56) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14197360 | 0.85 | CSF1R (0.53) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14197869 | 0.81 | CSF1R (0.43) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14196173 | 0.81 | CSF1R (0.61) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL14194083 | 0.80 | CYP3A4 (0.40) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL2181556 | 0.77 | CYP3A4 (0.69) | CYP3A4CYP2C19CYP2D6CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008063888-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |