Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194093 | 0.90 | CSF1R (0.56) | CSF1RKITMETGPR84CYP2C19 | |
| SCHEMBL14197867 | 0.89 | CSF1R (0.53) | CSF1RKITMETGPR84CYP2C19 | |
| SCHEMBL14198419 | 0.87 | CSF1R (0.61) | CSF1RKITMETGPR84CYP2C19 | |
| SCHEMBL14194091 | 0.87 | CYP3A4 (0.60) | CSF1RKITCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL14196175 | 0.86 | CSF1R (0.51) | CSF1RKITMETGPR84CYP2C19 | |
| SCHEMBL14194082 | 0.85 | CYP3A4 (0.48) | CSF1RKITCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL14198428 | 0.85 | CYP3A4 (0.48) | CSF1RKITCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL14194096 | 0.85 | CYP3A4 (0.48) | CSF1RKITCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL14196169 | 0.84 | CSF1R (0.56) | CSF1RKITMETGPR84CYP2C19 | |
| SCHEMBL14194977 | 0.84 | CYP3A4 (0.45) | CSF1RKITMETGPR84CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |