Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118676 | 0.69 | SMN1; SMN2 (0.57) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL4494376 | 0.65 | IGF1R (0.79) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL13919312 | 0.64 | IGF1R (0.48) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL4498917 | 0.63 | IGF1R (0.54) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL13919302 | 0.63 | IGF1R (0.76) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL4208158 | 0.63 | IGF1R (0.76) | IGF1RBRD4BRPF1EP300CREBBP | |
| SCHEMBL94996 | 0.62 | IGF1R (1.00) | IGF1RALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL13933186 | 0.61 | IGF1R (0.51) | IGF1RALDH1A1POLBKMT2AMAPT | |
| SCHEMBL13933182 | 0.60 | IGF1R (0.50) | IGF1RALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7122223 | 0.60 | IGF1R (0.71) | IGF1RALDH1A1POLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076278-A2 | METHODS OF CANCER TREATMENT WITH IGF1R INHIBITORS | SCHERING CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |