Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196304 | 0.81 | PDE10A (0.34) | IRAK4FYN | |
| SCHEMBL14196317 | 0.80 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL14196447 | 0.80 | IRAK4 (0.41) | IRAK4 | |
| SCHEMBL14197177 | 0.79 | IRAK4 (0.38) | IRAK4 | |
| SCHEMBL14196014 | 0.78 | JAK3 (0.33) | IRAK4 | |
| SCHEMBL14196626 | 0.78 | IRAK4 (0.36) | IRAK4FYNABL1RIN1CHRM3 | |
| SCHEMBL14196636 | 0.78 | ABL1 (0.34) | IRAK4ABL1RIN1JAK2JAK1 | |
| SCHEMBL14197166 | 0.78 | IRAK4 (0.33) | IRAK4FYN | |
| SCHEMBL14196298 | 0.77 | CDC7 (0.31) | — | |
| SCHEMBL14197179 | 0.77 | ADORA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |