Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.64 |
| ▸ | SRC | P12931 | 10/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.64 |
| ▸ | PRKCA | P17252 | 6/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.64 |
| ▸ | BCR | P11274 | 15/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224137 | 0.89 | ABL1 (0.66) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14224139 | 0.85 | ABL1 (0.63) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14196032 | 0.82 | ABL1 (0.56) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14196030 | 0.81 | ABL1 (0.58) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14196036 | 0.79 | ABL1 (0.53) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL9588 | 0.78 | ABL1 (1.00) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14196031 | 0.78 | ABL1 (0.51) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL4901346 | 0.76 | ABL1 (0.74) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL7468958 | 0.76 | ABL1 (0.76) | ABL1SRCPDGFRBPDGFRAPRKCA | |
| SCHEMBL14196033 | 0.76 | ABL1 (0.54) | ABL1SRCPDGFRBPDGFRAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |