Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.76 |
| ▸ | BCR | P11274 | 16/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.76 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.76 |
| ▸ | SRC | P12931 | 9/20 | 0.76 |
| ▸ | PRKCA | P17252 | 7/20 | 0.76 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.74 |
| ▸ | PRKCG | P05129 | 1/20 | 0.74 |
| ▸ | PRKCB | P05771 | 1/20 | 0.74 |
| ▸ | PRKCH | P24723 | 1/20 | 0.74 |
| ▸ | PRKCI | P41743 | 1/20 | 0.74 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.74 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.74 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.74 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.74 |
| ▸ | PLK1 | P53350 | 1/20 | 0.70 |
| ▸ | ABL2 | P42684 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736544 | 0.92 | PLK1 (0.76) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL7475764 | 0.89 | JAK2 (0.71) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL7465651 | 0.89 | ABL1 (0.76) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL7465138 | 0.88 | ABL1 (0.80) | ABL1BCRPDGFRBPDGFRASRC | |
| Cyclohexane SCHEMBL5776701 | 0.86 | ABL1 (0.76) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL1522 | 0.86 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL4901346 | 0.86 | ABL1 (0.74) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL19556857 | 0.85 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL4733852 | 0.85 | PLK1 (0.84) | ABL1BCRPDGFRBPDGFRASRC | |
| SCHEMBL1430 | 0.85 | ABL1 (1.00) | ABL1BCRPDGFRBPDGFRASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |