Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | ITGAL | P20701 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875465 | 0.91 | RAB9A (0.63) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL14196468 | 0.89 | RAB9A (0.60) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL6255206 | 0.82 | RAB9A (0.58) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL6336597 | 0.82 | RAB9A (0.56) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL12875489 | 0.81 | KDM4E (0.60) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL12875498 | 0.81 | RAB9A (0.71) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL12875471 | 0.81 | RAB9A (0.72) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL4827487 | 0.80 | PTGER4 (0.77) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL12875487 | 0.79 | KDM4E (0.76) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL12875461 | 0.79 | KDM4E (0.58) | RAB9ANPC1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |