Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.64 |
| ▸ | PDE1A | P54750 | 3/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049406 | 0.89 | MET (0.65) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910377 | 0.89 | MET (0.77) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL9910375 | 0.89 | MET (0.77) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL14198922 | 0.89 | MET (0.81) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL12101261 | 0.89 | MET (0.81) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL14198921 | 0.89 | MET (0.81) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL12049425 | 0.87 | MET (0.61) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL12049418 | 0.86 | MET (0.61) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL12048999 | 0.86 | MET (0.80) | METPDE1APDE4CPDE4DPDE3B | |
| SCHEMBL12049408 | 0.86 | MET (0.61) | METPDE1APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008051805-A2 | TRIAZOLO-PYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |