Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927841 | 0.85 | CNR2 (0.65) | ALDH1A1SMN1; SMN2CNR2KMT2AADORA1 | |
| SCHEMBL19232823 | 0.81 | CREBBP (0.64) | ALDH1A1SMN1; SMN2KMT2ACREBBPL3MBTL1 | |
| SCHEMBL3242026 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KMT2ANR4A2 | |
| SCHEMBL19234284 | 0.77 | PTPN7 (0.61) | ALDH1A1SMN1; SMN2CNR2KMT2ANR4A2 | |
| SCHEMBL19234287 | 0.77 | KMT2A (0.51) | ALDH1A1CNR2KMT2AADORA1NR4A2 | |
| SCHEMBL19233876 | 0.74 | KDM4E (0.70) | ALDH1A1SMN1; SMN2CNR2KMT2ANR4A2 | |
| SCHEMBL8527697 | 0.71 | MEN1 (0.55) | ALDH1A1SMN1; SMN2KMT2AHDAC1HDAC6 | |
| SCHEMBL1538812 | 0.69 | NR4A2 (0.66) | ALDH1A1SMN1; SMN2KMT2AADORA1NR4A2 | |
| SCHEMBL15155216 | 0.69 | KAT2B (0.65) | ALDH1A1SMN1; SMN2KMT2ACREBBPL3MBTL1 | |
| SCHEMBL7778088 | 0.69 | CNR2 (0.70) | ALDH1A1SMN1; SMN2CNR2KMT2ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608627-B1 | BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |