Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 3/20 | 0.43 |
| ▸ | CD74 | P04233 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198764 | 0.81 | MIF (0.65) | HPGDUSP2TSHRMIFCD74 | |
| SCHEMBL14198758 | 0.81 | IDO1 (0.66) | IDO1KMONOS3NOS1NOS2 | |
| SCHEMBL17529312 | 0.79 | MIF (0.48) | HPGDMAPK1USP2TSHRMIF | |
| SCHEMBL18171842 | 0.79 | MIF (0.70) | MIFCD74IDO1ALDH1A1KMT2A | |
| SCHEMBL14198763 | 0.78 | MAPK1 (0.70) | HPGDMAPK1USP2TSHRMIF | |
| SCHEMBL27631646 | 0.78 | IDO1 (0.43) | HPGDMAPK1USP2TSHRMIF | |
| SCHEMBL655852 | 0.77 | HPGD (0.66) | HPGDMAPK1IDO1KMOSMN1; SMN2 | |
| SCHEMBL10504839 | 0.77 | IDO1 (0.42) | HPGDMAPK1USP2TSHRMIF | |
| SCHEMBL8568187 | 0.75 | SIGMAR1 (0.51) | TSHRMIFCD74IDO1ALDH1A1 | |
| SCHEMBL9278836 | 0.74 | MIF (0.43) | HPGDMAPK1USP2TSHRMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608627-B1 | BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |