SCHEMBL14200071

SCHEMBL14200071

CCCCc1ccc(N(c2ccc(C)cc2)c2ccc(/C=C/c3ccc(N(c4ccc(C)cc4)c4ccc(CCCC)cc4)cc3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.44
CYP2D6 P10635 4/20 0.44
CYP2C9 P11712 4/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
SPHK1 Q9NYA1 2/20 0.43
CNR2 P34972 1/20 0.43
TRPM2 O94759 2/20 0.41
KDM4A O75164 2/20 0.41
KDM2A Q9Y2K7 2/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GRIN1 Q05586 1/20 0.41
GRIN2A Q12879 1/20 0.41
GRIN2B Q13224 1/20 0.41
GRIN2C Q14957 1/20 0.41
GRIN3A Q8TCU5 1/20 0.41
NFE2L2 Q16236 1/20 0.40
TP53 P04637 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16489729 1.00 CYP3A4 (0.44) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL12593363 1.00 CYP3A4 (0.44) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL16489750 1.00 CYP3A4 (0.44) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL15678724 0.95 RARB (0.43) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL13020946 0.94 CYP3A4 (0.47) CYP3A4CYP2D6CYP2C9SPHK1TRPM2
SCHEMBL18680258 0.94 CYP3A4 (0.42) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL7718254 0.93 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL9915627 0.93 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CA1CA2
SCHEMBL16489741 0.90 RELA (0.57) CYP3A4TP53LMNAHPGDCYP1A2
SCHEMBL13239570 0.90 CNR2 (0.45) CYP3A4CYP2D6CYP2C9CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9574084-B2 Hole transport composition E I DU PONT DE NEMOURS AND COMPANY (US) 2017-02-21 US disclosed
US-20130150536-A1 HOLE TRANSPORT COMPOSITION E I DU PONT DE NEMOURS AND COMPANY (US) 2013-06-13 US disclosed
US-8343381-B1 Hole transport composition E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-01 US disclosed
US-20080097076-A1 HOLE TRANSPORT POLYMERS E. I. DU PONT DE NEMOURS AND COMPANY 2008-04-24 US disclosed