SCHEMBL14200077

SCHEMBL14200077

Cc1ccc(N(c2ccc(-c3ccc(N(c4ccc(C)cc4)c4ccc(C(F)(F)F)cc4)cc3)cc2)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 11/20 0.50
NPBWR1 P48145 1/20 0.41
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
MAOB P27338 1/20 0.39
AR P10275 1/20 0.39
ALDH1A1 P00352 2/20 0.38
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17409153 1.00 KIF11 (0.50) KIF11NPBWR1CYP1A1CYP1B1MAOB
SCHEMBL17409156 1.00 KIF11 (0.50) KIF11NPBWR1CYP1A1CYP1B1MAOB
SCHEMBL9999807 0.94 TSHR (0.42) KIF11CYP1A1CYP1B1ALDH1A1BCHE
SCHEMBL17110032 0.87 KIF11 (0.61) KIF11NPBWR1CYP1A1CYP1B1MAOB
SCHEMBL13019482 0.87 KIF11 (0.61) KIF11NPBWR1CYP1A1CYP1B1MAOB
SCHEMBL1044865 0.87 KIF11 (0.61) KIF11NPBWR1CYP1A1CYP1B1MAOB
SCHEMBL20100708 0.87 CYP1A1 (0.48) KIF11CYP1A1CYP1B1
SCHEMBL14210110 0.84 NPC1 (0.51) ALDH1A1TSHR
SCHEMBL15615059 0.83 TSHR (0.46) KIF11ALDH1A1ACHETSHR
SCHEMBL18193972 0.83 KIF11 (0.50) KIF11CYP1A1CYP1B1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9574084-B2 Hole transport composition E I DU PONT DE NEMOURS AND COMPANY (US) 2017-02-21 US disclosed
US-20130150536-A1 HOLE TRANSPORT COMPOSITION E I DU PONT DE NEMOURS AND COMPANY (US) 2013-06-13 US disclosed
US-8343381-B1 Hole transport composition E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-01 US disclosed
US-20080097076-A1 HOLE TRANSPORT POLYMERS E. I. DU PONT DE NEMOURS AND COMPANY 2008-04-24 US disclosed