Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.47 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201307 | 0.91 | CA9 (0.53) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13589872 | 0.91 | GLA (0.53) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3694171 | 0.89 | CNR2 (0.58) | CNR2ESR2PSEN1PSEN2APH1B | |
| SCHEMBL14200191 | 0.87 | CA12 (0.51) | CNR2ESR2PSEN1PSEN2APH1B | |
| SCHEMBL14200193 | 0.87 | MEN1 (0.52) | CNR2ESR2SMN1; SMN2POLBCA12 | |
| SCHEMBL14229013 | 0.86 | CA9 (0.61) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14200203 | 0.85 | CNR2 (0.53) | CNR2ESR2SMN1; SMN2RAB9AHTT | |
| SCHEMBL8101278 | 0.84 | CNR2 (0.64) | CNR2SMN1; SMN2POLBCA12CA9 | |
| SCHEMBL14200195 | 0.84 | CA12 (0.48) | ESR2SMN1; SMN2POLBCA12CA9 | |
| SCHEMBL14200198 | 0.83 | MAPT (0.55) | ESR2SMN1; SMN2POLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |