Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 8/20 | 0.61 |
| ▸ | CA12 | O43570 | 7/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.61 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.61 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.61 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.61 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 5/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694171 | 0.96 | CNR2 (0.58) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL9361266 | 0.95 | CA9 (0.63) | CA9CA12CA2SMN1; SMN2RAB9A | |
| Ditolamide SCHEMBL2110790 | 0.93 | CA9 (0.64) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL8101278 | 0.91 | CNR2 (0.64) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL8626916 | 0.90 | SMN1; SMN2 (0.58) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL7611913 | 0.90 | CNR2 (0.67) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL2469274 | 0.90 | KDM4E (0.59) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL9307801 | 0.90 | CNR2 (0.67) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL12391143 | 0.87 | SMN1; SMN2 (0.58) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL14200224 | 0.86 | CNR2 (0.50) | CA9CA12CA2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |