Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200221 | 0.90 | CES1 (0.33) | — | |
| SCHEMBL14518426 | 0.89 | CA1 (0.39) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200214 | 0.86 | CA1 (0.36) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200184 | 0.85 | CA1 (0.48) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200207 | 0.84 | CA1 (0.38) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200212 | 0.83 | CA1 (0.34) | CA1CA12CA14CA2 | |
| SCHEMBL14229343 | 0.81 | CA1 (0.41) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200360 | 0.81 | CA1 (0.35) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200208 | 0.79 | CA1 (0.43) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200209 | 0.79 | CES1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |