Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229111 | 0.85 | CA1 (0.58) | CA1CA12CA14CA2MEN1 | |
| SCHEMBL14200366 | 0.83 | CA1 (0.68) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200368 | 0.82 | CA1 (0.54) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200186 | 0.76 | CA1 (0.34) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200184 | 0.75 | CA1 (0.48) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14201305 | 0.75 | CA1 (0.40) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200353 | 0.74 | CA1 (0.39) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200318 | 0.73 | CA1 (0.40) | CA1CA12CA2MEN1KMT2A | |
| SCHEMBL14229180 | 0.72 | CA1 (0.79) | CA1CA12CA14CA2CA7 | |
| SCHEMBL14200363 | 0.72 | FAAH (0.38) | CA1CA12CA14CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |