Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200313 | 0.93 | NOTUM (0.44) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL14229159 | 0.85 | NOTUM (0.50) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL30954331 | 0.79 | NOTUM (0.59) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL2692515 | 0.79 | NOTUM (0.59) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL29428949 | 0.71 | NOTUM (0.65) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL3834965 | 0.71 | NOTUM (0.65) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL30452423 | 0.68 | NOTUM (0.61) | NOTUMTSHRRAB9AL3MBTL1LMNA | |
| SCHEMBL3004386 | 0.68 | NOTUM (0.61) | NOTUMTSHRRAB9AL3MBTL1LMNA | |
| SCHEMBL28978894 | 0.68 | NOTUM (0.56) | NOTUMTSHRRAB9AL3MBTL1LMNA | |
| SCHEMBL2997057 | 0.68 | NOTUM (0.65) | NOTUMTSHRRAB9AL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |