Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200313 | 0.89 | NOTUM (0.44) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL14200317 | 0.85 | NOTUM (0.47) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL30954331 | 0.82 | NOTUM (0.59) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL2692515 | 0.82 | NOTUM (0.59) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL17765488 | 0.75 | P2RX4 (0.43) | SLC6A2P2RX4TACR1TP53LMNA | |
| SCHEMBL28244322 | 0.75 | NOTUM (0.57) | NOTUMTSHRRAB9AL3MBTL1LMNA | |
| SCHEMBL414272 | 0.75 | LTB4R2 (0.40) | NOTUMTACR1LMNAALDH1A1GAA | |
| SCHEMBL15298782 | 0.75 | TACR1 (0.42) | BCHETACR1TP53 | |
| SCHEMBL3834965 | 0.74 | NOTUM (0.65) | NOTUMBCHETSHRRAB9AL3MBTL1 | |
| SCHEMBL29428949 | 0.74 | NOTUM (0.65) | NOTUMBCHETSHRRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |