Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200663 | 0.95 | — | — | |
| SCHEMBL14200723 | 0.95 | NFKB1 (0.32) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14200755 | 0.90 | — | — | |
| SCHEMBL14200719 | 0.90 | NFKB1 (0.33) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14230235 | 0.90 | KDM4E (0.31) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14229049 | 0.87 | NFKB1 (0.36) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14200710 | 0.86 | — | — | |
| SCHEMBL14200687 | 0.85 | NFKB1 (0.31) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14200722 | 0.84 | KDM4E (0.31) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL14230232 | 0.84 | KDM4E (0.31) | NFKB1L3MBTL1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |