Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200757 | 0.91 | NFKB1 (0.35) | MAPTSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL14200678 | 0.91 | NPC1 (0.30) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14200756 | 0.89 | MAPT (0.33) | MAPTSMN1; SMN2AOC3 | |
| SCHEMBL14200715 | 0.84 | NFKB1 (0.35) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL19891748 | 0.84 | AOC3 (0.33) | MAPTSMN1; SMN2AOC3NUDT1 | |
| SCHEMBL14229191 | 0.81 | SMN1; SMN2 (0.37) | MAPTSMN1; SMN2AOC3NPC1RAB9A | |
| SCHEMBL14200647 | 0.79 | HTT (0.31) | SMN1; SMN2 | |
| SCHEMBL14230156 | 0.78 | SMN1; SMN2 (0.35) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL14200686 | 0.77 | — | — | |
| SCHEMBL14200710 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |