Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 2/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201089 | 0.92 | PDE5A (0.35) | AKR1B1UBE2MDCUN1D1MAPK14RIPK1 | |
| SCHEMBL14200977 | 0.90 | AKR1B1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14200974 | 0.89 | AKR1B1 (0.34) | AKR1B1TAS1R3TAS1R1UBE2MDCUN1D1 | |
| SCHEMBL14543478 | 0.86 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14200825 | 0.84 | POLB (0.33) | AKR1B1RIPK1HPGDALDH1A1MEN1 | |
| SCHEMBL14201091 | 0.84 | AKR1B1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14201197 | 0.83 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14200779 | 0.81 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14229315 | 0.80 | PSEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14201018 | 0.80 | PSEN1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |