Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178548 | 0.96 | BACE1 (0.50) | BACE1DRD1PPARAPPARG | |
| SCHEMBL8367031 | 0.91 | BACE1 (0.47) | BACE1DRD1PPARAPPARGMRGPRX4 | |
| SCHEMBL8411825 | 0.86 | DRD1 (0.43) | BACE1DRD1PPARAPPARGMRGPRX4 | |
| SCHEMBL3164761 | 0.86 | BACE1 (0.42) | BACE1DRD1 | |
| SCHEMBL3152374 | 0.86 | BACE1 (0.42) | BACE1DRD1 | |
| SCHEMBL27740487 | 0.85 | BACE1 (0.51) | BACE1PPARAPPARGLMNAMRGPRX4 | |
| SCHEMBL9061224 | 0.85 | RARB (0.47) | BACE1DRD1PPARA | |
| SCHEMBL8365618 | 0.84 | DRD1 (0.43) | BACE1DRD1PPARAPPARGMRGPRX4 | |
| SCHEMBL8367054 | 0.83 | BACE1 (0.50) | BACE1DRD1PPARAPPARGMRGPRX4 | |
| SCHEMBL8194931 | 0.83 | BACE1 (0.50) | BACE1DRD1PPARAPPARGMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038271-A9 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH CORP (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2007038271-A1 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH (US) | 2007-04-05 | — | — | WO | disclosed |