Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.51 |
| ▸ | DAO | P14920 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14378253 | 0.89 | PPARA (0.47) | BACE1DAOPPARAPPARGLMNA | |
| SCHEMBL14378255 | 0.86 | PPARA (0.52) | BACE1DAOPPARAPPARG | |
| SCHEMBL8990952 | 0.86 | RARB (0.46) | BACE1DAOPPARA | |
| SCHEMBL8990685 | 0.86 | RARB (0.46) | BACE1DAOPPARA | |
| SCHEMBL14201366 | 0.85 | BACE1 (0.49) | BACE1PPARAPPARGMRGPRX4LMNA | |
| SCHEMBL9061224 | 0.84 | RARB (0.47) | BACE1DAOPPARA | |
| SCHEMBL11090033 | 0.84 | PPARA (0.52) | BACE1DAOPPARALMNA | |
| SCHEMBL27740478 | 0.82 | BACE1 (0.52) | BACE1DAOPPARAPPARGMRGPRX4 | |
| SCHEMBL21234441 | 0.82 | PPARA (0.55) | PPARALMNA | |
| SCHEMBL3456499 | 0.82 | BACE1 (0.47) | BACE1PPARAPPARGMRGPRX4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273018-A | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | WYETH CORP (US) | 2008-09-24 | — | — | CN | disclosed |