Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12690965 | 0.86 | MEN1 (0.45) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL29953365 | 0.81 | QRFPR (0.47) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL4733145 | 0.80 | MEN1 (0.39) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL4734547 | 0.80 | MEN1 (0.39) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL12678687 | 0.80 | GAA (0.40) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL11782294 | 0.78 | MEN1 (0.64) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL29956300 | 0.77 | QRFPR (0.46) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL12678325 | 0.77 | MEN1 (0.37) | MEN1KMT2AKDM4EGAAHTT | |
| SCHEMBL29955155 | 0.76 | QRFPR (0.54) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL27091860 | 0.76 | MEN1 (0.65) | MEN1KMT2AKDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057469-A1 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057468-A1 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS, INC. (US) | 2008-05-15 | — | — | WO | disclosed |