Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280734 | 0.93 | CHEK1 (0.48) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2279230 | 0.93 | CHEK1 (0.48) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2286875 | 0.85 | CHEK1 (0.45) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2286880 | 0.85 | CHEK1 (0.45) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2286027 | 0.82 | CHEK1 (0.62) | CHEK1 | |
| SCHEMBL2286032 | 0.82 | CHEK1 (0.62) | CHEK1 | |
| SCHEMBL2282387 | 0.80 | CHEK1 (0.54) | CHEK1 | |
| SCHEMBL2282382 | 0.80 | CHEK1 (0.54) | CHEK1 | |
| SCHEMBL2282350 | 0.79 | CHEK1 (0.46) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2341719 | 0.79 | CHEK1 (0.40) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053182-A1 | IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |