Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.48 |
| ▸ | IKBKB | O14920 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279230 | 1.00 | CHEK1 (0.48) | CHEK1IKBKBJAK2JAK3MAPK14 | |
| SCHEMBL14204841 | 0.93 | CHEK1 (0.42) | CHEK1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2286875 | 0.92 | CHEK1 (0.45) | CHEK1IKBKBJAK2JAK3MAPK14 | |
| SCHEMBL2286880 | 0.92 | CHEK1 (0.45) | CHEK1IKBKBJAK2JAK3MAPK14 | |
| SCHEMBL2286027 | 0.89 | CHEK1 (0.62) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2286032 | 0.89 | CHEK1 (0.62) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2282387 | 0.87 | CHEK1 (0.54) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2282382 | 0.87 | CHEK1 (0.54) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2341719 | 0.86 | CHEK1 (0.40) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL2282357 | 0.86 | CHEK1 (0.46) | CHEK1IKBKBMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | claimed |
| US-8003695-B2 | IKK-beta serine-threonine protein kinase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-08-23 | — | — | US | claimed |
| EP-2078007-A1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-07-15 | — | — | EP | claimed |
| WO-2008053182-A1 | IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | claimed |
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | disclosed |