Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AGER | Q15109 | 5/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283067 | 0.97 | AGER (0.53) | MAPTAGERHRH4HRH2HRH1 | |
| SCHEMBL1283065 | 0.97 | AGER (0.49) | MAPTAGERHRH4HRH2HRH1 | |
| SCHEMBL1283792 | 0.96 | AGER (0.51) | MAPTAGERDRD2DRD3ESR1 | |
| SCHEMBL1283563 | 0.94 | MAPT (0.46) | MAPTAGERHRH4HRH2HRH1 | |
| SCHEMBL1283170 | 0.94 | AGER (0.52) | MAPTAGERHRH4DRD2DRD3 | |
| SCHEMBL1283281 | 0.93 | ESR1 (0.54) | MAPTAGERDRD2DRD3ESR1 | |
| SCHEMBL1283809 | 0.93 | ESR1 (0.54) | MAPTAGERDRD2DRD3ESR1 | |
| SCHEMBL1282811 | 0.91 | ESR1 (0.45) | MAPTAGERHRH4HRH2HRH1 | |
| SCHEMBL1282993 | 0.91 | ESR1 (0.46) | MAPTAGERDRD2DRD3ESR1 | |
| SCHEMBL1283432 | 0.91 | BRD4 (0.50) | MAPTAGERESR1HRH3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361678-B2 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | TRANSTECH PHARMA, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361678-B2 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | TRANSTECH PHARMA, INC. (US) | 2008-04-22 | — | — | US | disclosed |