Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376538 | 0.81 | MET (1.00) | METCNR1KDREPHX2SCN3A | |
| SCHEMBL12376534 | 0.76 | MET (1.00) | METCNR1KDREPHX2 | |
| SCHEMBL24134180 | 0.72 | PDE4A (0.47) | METKDR | |
| SCHEMBL6568477 | 0.72 | CNR1 (0.68) | METCNR1EPHX2KDM1ACA1 | |
| SCHEMBL22834265 | 0.69 | CNR1 (1.00) | METCNR1EPHX2KDM1AMAOB | |
| SCHEMBL22834156 | 0.69 | CNR1 (1.00) | METCNR1EPHX2KDM1AMAOB | |
| SCHEMBL22834153 | 0.69 | CNR1 (1.00) | METCNR1EPHX2KDM1AMAOB | |
| SCHEMBL1492971 | 0.68 | MAPK1 (0.61) | METCNR1EPHX2IDH1 | |
| SCHEMBL12410273 | 0.64 | MET (0.65) | METCNR1KDREPHX2IDH1 | |
| SCHEMBL8350625 | 0.63 | SMN1; SMN2 (0.70) | CNR1EPHX2KDM1ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063202-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | ARRAY BIOPHARMA INC. (US) | 2008-05-29 | — | — | WO | disclosed |