Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733284 | 0.85 | HTR2A (0.49) | HTR2AHTR2CPRKAA2HTR7HTR6 | |
| SCHEMBL9426176 | 0.78 | MEN1 (0.60) | HTR2AHTR2CPRKAA2HTR7HTR6 | |
| SCHEMBL14205783 | 0.77 | HTR2A (0.53) | HTR2AHTR2CPRKAA2HTR7DRD4 | |
| SCHEMBL3144485 | 0.76 | HTR2A (0.62) | HTR2AHTR2CPRKAA2 | |
| SCHEMBL17444707 | 0.74 | MEN1 (0.59) | PRKAA2 | |
| SCHEMBL14205205 | 0.74 | HTR2A (0.60) | HTR2AHTR2C | |
| SCHEMBL9513154 | 0.74 | MEN1 (0.68) | HTR2AHTR2CPRKAA2HTR7HTR6 | |
| SCHEMBL3134453 | 0.73 | HTR2A (0.71) | HTR2AHTR2CPRKAA2 | |
| SCHEMBL3140015 | 0.72 | HTR2A (0.63) | HTR2AHTR2CPRKAA2 | |
| SCHEMBL4783828 | 0.72 | HTR2A (0.62) | HTR2AHTR2CTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |