Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.62 |
| ▸ | HTR2C | P28335 | 5/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784178 | 0.87 | HTR2A (0.66) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4781253 | 0.85 | HTR2A (0.61) | HTR2AHTR2CDRD2KCNH2TMEM97 | |
| SCHEMBL4782110 | 0.85 | HTR2A (0.54) | HTR2AHTR2CDRD2KCNH2TMEM97 | |
| SCHEMBL4780094 | 0.85 | HTR2A (0.67) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3140063 | 0.80 | HTR2A (0.72) | HTR2AHTR2CKCNH2TMEM97MEN1 | |
| SCHEMBL4780625 | 0.77 | HTR2A (0.64) | HTR2AHTR2CDRD2KCNH2MEN1 | |
| SCHEMBL4781375 | 0.77 | PTGS1 (0.58) | HTR2AHTR2CDRD2KCNH2TMEM97 | |
| SCHEMBL3139495 | 0.77 | HTR2A (1.00) | HTR2AHTR2CKCNH2 | |
| SCHEMBL3143258 | 0.76 | HTR2A (0.62) | HTR2AHTR2CKCNH2TMEM97KMT2A | |
| SCHEMBL4848833 | 0.75 | HTR2A (0.63) | HTR2AHTR2CTHRBDRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | claimed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |