Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516634 | 0.82 | DYRK1A (0.36) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL12762851 | 0.81 | DYRK1A (0.35) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL4099333 | 0.80 | DYRK1A (0.41) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL14231805 | 0.75 | DYRK1A (0.39) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL18458801 | 0.74 | LMNA (0.30) | LMNA | |
| SCHEMBL11637557 | 0.74 | MAPT (0.51) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL4098480 | 0.72 | DYRK1A (0.42) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL760353 | 0.72 | NPC1 (0.48) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL1433126 | 0.72 | DYRK1A (0.42) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 | |
| SCHEMBL1516710 | 0.71 | DYRK1A (0.43) | DYRK1ADYRK1BL3MBTL1NPC1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361763-B2 | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2008-04-22 | — | — | US | disclosed |