Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FSHR | P23945 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421185 | 0.83 | AAK1 (0.35) | BACE1CYP17A1TSHRFSHR | |
| SCHEMBL3178464 | 0.80 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL3178451 | 0.80 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL1420964 | 0.78 | BACE1 (0.39) | BACE1CTSDBACE2 | |
| SCHEMBL932026 | 0.78 | BACE1 (0.34) | BACE1CTSDBACE2ABL1 | |
| SCHEMBL933479 | 0.78 | BACE1 (0.34) | BACE1CTSDBACE2ABL1 | |
| SCHEMBL1420867 | 0.76 | BACE1 (0.60) | BACE1CTSDBACE2 | |
| SCHEMBL15322627 | 0.76 | BACE1 (0.60) | BACE1CTSDBACE2 | |
| SCHEMBL1421136 | 0.73 | ABL1 (0.36) | BACE1CTSDBACE2CYP17A1ABL1 | |
| SCHEMBL1424309 | 0.73 | ABL1 (0.36) | BACE1CTSDBACE2CYP17A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297120-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009134617-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2009-11-05 | — | — | WO | disclosed |