Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104718 | 0.89 | HSD11B1 (0.75) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL5104721 | 0.89 | HSD11B1 (0.75) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL4047995 | 0.88 | HSD11B1 (0.71) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL4047996 | 0.88 | HSD11B1 (0.71) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL5104751 | 0.88 | HSD11B1 (0.71) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL14208992 | 0.88 | HSD11B1 (0.71) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL14209074 | 0.85 | HSD11B1 (0.78) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL3951392 | 0.85 | HSD11B1 (0.75) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL3951395 | 0.85 | HSD11B1 (0.75) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL4045121 | 0.83 | HSD11B1 (0.84) | HSD11B1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365075-B2 | Aryl sulfonamide compounds and uses related thereto | AMGEN INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365075-B2 | Aryl sulfonamide compounds and uses related thereto | AMGEN INC. (US) | 2008-04-29 | — | — | US | disclosed |