Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 8/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421083 | 0.91 | SYK (0.37) | SYKBACE1CYP17A1KCNH2BRD4 | |
| SCHEMBL1420884 | 0.89 | SYK (0.37) | SYKBACE1CYP17A1KCNH2BRD4 | |
| SCHEMBL1420673 | 0.86 | BACE1 (0.39) | BACE1CYP17A1ABL1 | |
| SCHEMBL1420882 | 0.84 | HCRTR1 (0.36) | BACE1BRD4CREBBPHCRTR1HCRTR2 | |
| SCHEMBL3171758 | 0.80 | BACE1 (0.40) | SYKBACE1CYP17A1KCNH2BRD4 | |
| SCHEMBL4310210 | 0.79 | BACE1 (0.38) | BACE1KCNH2CCR2ABL1CNR1 | |
| SCHEMBL1421136 | 0.77 | ABL1 (0.36) | BACE1CYP17A1ABL1 | |
| SCHEMBL1424309 | 0.77 | ABL1 (0.36) | BACE1CYP17A1ABL1 | |
| SCHEMBL1421023 | 0.77 | BACE1 (0.38) | BACE1CYP17A1HCRTR1HCRTR2CCR2 | |
| SCHEMBL1421032 | 0.76 | BACE1 (0.38) | SYKBACE1CYP17A1KCNH2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297120-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009134617-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 2009-11-05 | — | — | WO | disclosed |