Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | CBR1 | P16152 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | ACLY | P53396 | 1/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.37 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182165 | 1.00 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14182170 | 1.00 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14212857 | 1.00 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL10149964 | 1.00 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL19418325 | 0.92 | HSP90AB1 (0.68) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL10150412 | 0.89 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL10149963 | 0.89 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL14212855 | 0.89 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL20840799 | 0.89 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL2622302 | 0.89 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | BDKRB1, RPS4Y1, GRK4 | HSP90AB1 3784/4885MAPT 4737/4885HSP90AA1 4330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.