Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.73 |
| ▸ | CBR1 | P16152 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | ACLY | P53396 | 1/20 | 0.73 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cycloproparadicicol SCHEMBL20840799 | 1.00 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL10150412 | 1.00 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL14212855 | 1.00 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| Cycloproparadicicol SCHEMBL2622302 | 1.00 | HSP90AB1 (1.00) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL19418326 | 0.92 | HSP90AB1 (0.85) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14212857 | 0.89 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14212864 | 0.89 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14182170 | 0.89 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL14182165 | 0.89 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A | |
| SCHEMBL10149964 | 0.89 | HSP90AB1 (0.80) | HSP90AB1MAPTHSP90AA1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782649-B1 | BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2025-05-14 | — | — | EP | disclosed |
| US-11873310-B2 | Compounds useful in HIV therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2024-01-16 | — | — | US | disclosed |
| US-20230381323-A1 | RELEASABLE CONJUGATES | FISH & RICHARDSON PC | 2023-11-30 | — | — | US | disclosed |
| US-11786599-B2 | Releasable conjugates | QUIAPEG PHARMACEUTICALS AB (SE) | 2023-10-17 | — | — | US | disclosed |
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | ASCENDIS PHARMA A/S (DK) | 2023-04-20 | — | — | US | disclosed |
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | ASCENDIS PHARMA A/S (DE) | 2023-01-24 | — | — | US | disclosed |
| EP-4011396-A1 | RELEASABLE CONJUGATES | QuiaPEG Pharmaceuticals AB (SE) | 2022-06-15 | — | — | EP | disclosed |
| US-20220119417-A1 | Compounds Useful in HIV Therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-21 | — | — | US | disclosed |
| US-10975056-B2 | Substituted pyridines as inhibitors of DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-13 | — | — | US | disclosed |
| US-20210009609-A1 | Compounds Useful in HIV Therapy | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-01-14 | — | — | US | disclosed |
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-03-29 | — | — | US | disclosed |
| US-8067412-B2 | analogs of natural products radicicol and pochonins; (oxirane or cyclopropan) 2-benzoxacyclo(di)tetradecin derivatives; inhibition of kinase phosphorylation activity and heat shock proteins; anticarcinogenic, antiinflammatory agent; neurodegenerative diseases; antiallergen | UNIVERSITE DE STRASBOURG (FR) | 2011-11-29 | — | — | US | disclosed |
| US-20110190237-A1 | Macrocyclic Prodrug Compounds Useful as Therapeutics | NEXGENIX PHARMACEUTICALS (US) | 2011-08-04 | — | — | US | disclosed |
| US-20100292218-A1 | Treatment Of Neurofibromatosis With Radicicol And Its Derivatives | NEXGENIX PHARMACEUTICALS HOLDINGS, INC. | 2010-11-18 | — | — | US | disclosed |
| US-20100093824-A1 | METHODS OF TREATING VIRAL INFECTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-04-15 | — | — | US | disclosed |
| US-20100093824-A1 | METHODS OF TREATING VIRAL INFECTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-04-15 | — | — | US | disclosed |
| WO-2008143647-A2 | METHODS OF TREATING VIRAL INFECTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080146545-A1 | Macrocyclic compounds useful as inhibitors of kinases and HSP90 | UNIVERSITE DE STRASBOURG (FR) | 2008-06-19 | — | — | US | disclosed |
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-05-08 | — | — | US | disclosed |
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108694-A1 | Novel Macrocycles and Uses Thereof | BDKRB1, RPS4Y1, GRK4 | HSP90AB1 3784/4885MAPT 4737/4885HSP90AA1 4330/4885 |
| US-20120077775-A1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885MAPT 1982/4885HSP90AA1 2/4885 |
| US-20220119417-A1 | Compounds Useful in HIV Therapy | CD4, CCR5, ABCB1 | HSP90AB1 1471/4885MAPT 650/4885HSP90AA1 2339/4885 |
| US-20100093824-A1 | METHODS OF TREATING VIRAL INFECTION | EIF2AK2, NSUN2, NSUN3 | HSP90AB1 250/4885MAPT 2183/4885HSP90AA1 375/4885 |
| US-11873310-B2 | Compounds useful in HIV therapy | CD4, CCR5, ABCB1 | HSP90AB1 1471/4885MAPT 650/4885HSP90AA1 2339/4885 |
| US-20100292218-A1 | Treatment Of Neurofibromatosis With Radicicol And Its Derivatives | HSP90AB2P, HSP90AA1, HSPA2 | HSP90AB1 4/4885MAPT 2339/4885HSP90AA1 2/4885 |
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | PLG, PHYKPL, PLOD3 | HSP90AB1 80/4885MAPT 1671/4885HSP90AA1 164/4885 |
| US-10975056-B2 | Substituted pyridines as inhibitors of DNMT1 | DNMT1, DNMT3A, DNMT3B | HSP90AB1 4339/4885MAPT 3289/4885HSP90AA1 4617/4885 |
| US-20230381323-A1 | RELEASABLE CONJUGATES | GUSB, ABCB11, UGT2B7 | HSP90AB1 320/4885MAPT 3354/4885HSP90AA1 984/4885 |
| US-20080146545-A1 | Macrocyclic compounds useful as inhibitors of kinases and HSP90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AB1 1/4885MAPT 1982/4885HSP90AA1 2/4885 |
| US-20110190237-A1 | Macrocyclic Prodrug Compounds Useful as Therapeutics | ADCYAP1R1, CYP19A1, THOP1 | HSP90AB1 3953/4885MAPT 2173/4885HSP90AA1 4055/4885 |
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | PLG, PHYKPL, PLOD3 | HSP90AB1 80/4885MAPT 1671/4885HSP90AA1 164/4885 |
| US-11786599-B2 | Releasable conjugates | GUSB, ABCB11, UGT2B7 | HSP90AB1 320/4885MAPT 3354/4885HSP90AA1 984/4885 |
| US-20210009609-A1 | Compounds Useful in HIV Therapy | CD4, CCR5, ABCB1 | HSP90AB1 2177/4885MAPT 876/4885HSP90AA1 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.