Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14213771 | 0.90 | KDM4E (0.39) | KDM4ES1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL14213343 | 0.82 | S1PR2 (0.43) | KDM4EHTTS1PR2S1PR1S1PR3 | |
| SCHEMBL14182589 | 0.82 | SCN2A (0.39) | KDM4ETHRBTDP1HTTS1PR2 | |
| SCHEMBL14213086 | 0.80 | MAP4K1 (0.34) | S1PR2S1PR1S1PR3LPAR2ALDH1A1 | |
| SCHEMBL12841912 | 0.75 | KDM4E (0.46) | KDM4ETHRBTDP1HTTSMN1; SMN2 | |
| SCHEMBL14747737 | 0.75 | KDM4E (0.48) | KDM4ETHRBTDP1HTTSMN1; SMN2 | |
| SCHEMBL14182595 | 0.74 | KDM4E (0.48) | KDM4ETHRBTDP1HTTS1PR2 | |
| SCHEMBL14213088 | 0.74 | DPP7 (0.48) | MEN1KMT2A | |
| SCHEMBL12842028 | 0.73 | KDM4E (0.37) | KDM4EMEN1KMT2ALMNASCN8A | |
| SCHEMBL14182593 | 0.72 | KDM4E (0.38) | KDM4ETDP1HTTS1PR2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119451-A1 | Novel Benzamide Derivatives | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119451-A1 | Novel Benzamide Derivatives | HDAC1, HDAC11, HDAC2 | KDM4E 265/4885THRB 1247/4885TDP1 2140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.