Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171901 | 0.84 | L3MBTL1 (0.51) | KDM4ESCN8AGAACD274PDCD1 | |
| SCHEMBL14747536 | 0.82 | GAA (0.44) | TDP1POLBALDH1A1TP53SCN8A | |
| SCHEMBL20037934 | 0.80 | GAA (0.43) | KDM4ETDP1POLBALDH1A1TP53 | |
| SCHEMBL17888393 | 0.78 | ALDH1A1 (0.43) | KDM4ETDP1POLBALDH1A1TP53 | |
| SCHEMBL28103835 | 0.78 | HRH4 (0.59) | KDM4ESCN8ALMNASMN1; SMN2 | |
| SCHEMBL5833866 | 0.77 | MC4R (0.45) | KDM4EALDH1A1SCN8AGAACD274 | |
| SCHEMBL20999188 | 0.77 | CD274 (0.55) | SCN8AGAASMN1; SMN2CD274PDCD1 | |
| SCHEMBL7981959 | 0.77 | GAA (0.43) | KDM4ETDP1POLBALDH1A1TP53 | |
| SCHEMBL14213161 | 0.75 | KDM4E (0.38) | KDM4ETDP1THRBALDH1A1SCN8A | |
| SCHEMBL487644 | 0.74 | TSHR (0.39) | POLBLMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389541-B2 | Inhibitors of protein tyrosine kinase activity | METHYLGENE INC. (CA) | 2013-03-05 | — | — | US | disclosed |