SCHEMBL1421382

SCHEMBL1421382

COc1cc(O)c2c(=O)cc(-c3ccc(OC)c(OC)c3)oc2c1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 5/20 0.86
PLG P00747 1/20 0.77
IP6K2 Q9UHH9 3/20 0.76
FLT3 P36888 2/20 0.76
MAOB P27338 2/20 0.76
MKNK2 Q9HBH9 1/20 0.76
CYP19A1 P11511 1/20 0.76
CYP1A1 P04798 4/20 0.73
CYP1A2 P05177 4/20 0.73
MAPT P10636 3/20 0.73
ABCC1 P33527 3/20 0.73
MEN1 O00255 3/20 0.73
KMT2A Q03164 3/20 0.73
HDAC6 Q9UBN7 2/20 0.73
ALDH1A1 P00352 2/20 0.73
KDM1A O60341 1/20 0.73
XDH P47989 1/20 0.73
IPMK Q8NFU5 1/20 0.73
POLB P06746 1/20 0.73
ABCB1 P08183 4/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29845342 1.00 CYP1B1 (0.86) CYP1B1PLGIP6K2FLT3MAOB
Methane SCHEMBL27890494 0.99 CYP1B1 (0.84) CYP1B1PLGIP6K2FLT3MAOB
SCHEMBL27907057 0.99 CYP1B1 (0.84) CYP1B1PLGIP6K2FLT3MAOB
SCHEMBL30365934 0.92 CYP1B1 (1.00) CYP1B1PLGIP6K2FLT3MAOB
Velutin SCHEMBL29928535 0.92 CYP1B1 (0.86) CYP1B1PLGIP6K2FLT3MAOB
SCHEMBL29883103 0.92 CYP1B1 (1.00) CYP1B1PLGIP6K2FLT3MAOB
Velutin SCHEMBL5804380 0.92 CYP1B1 (0.86) CYP1B1PLGIP6K2FLT3MAOB
SCHEMBL2483636 0.92 CYP1B1 (1.00) CYP1B1PLGIP6K2FLT3MAOB
SCHEMBL26117114 0.92 CYP1B1 (0.86) CYP1B1PLGIP6K2FLT3MAOB
Tetramethylluteolin SCHEMBL29725288 0.88 ABCB1 (0.80) CYP1B1PLGCYP1A1CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117731774-A Application of 3',4', 7-O-trimethyl luteolin in preparation of photodynamic therapy photosensitizer 常州大学 2024-03-22 CN claimed
CN-116577430-A Method for identifying wide dried orange peel with different harvest periods in different years based on metabonomics 华南农业大学 2023-08-11 CN claimed
CN-117731774-A Application of 3',4', 7-O-trimethyl luteolin in preparation of photodynamic therapy photosensitizer 常州大学 2024-03-22 CN disclosed
CN-117731774-A Application of 3',4', 7-O-trimethyl luteolin in preparation of photodynamic therapy photosensitizer 常州大学 2024-03-22 CN disclosed
CN-117731774-A Application of 3',4', 7-O-trimethyl luteolin in preparation of photodynamic therapy photosensitizer 常州大学 2024-03-22 CN disclosed
CN-104231010-A Compound having antiviral activity and its preparation method and use HEILONGJIANG SONGHUAJIANG PHARMACEUTICAL CO LTD 2014-12-24 CN disclosed
CN-102879502-B Method for identifying lonicera similis hemsl high-quality medicinal materials UNIV CHENGDU TRAD CN MEDICINE 2014-07-23 CN disclosed
CN-102879502-B Method for identifying lonicera similis hemsl high-quality medicinal materials UNIV CHENGDU TRAD CN MEDICINE 2014-07-23 CN disclosed
CN-102924418-B Method for separating and purifying effective ingredients from fine felt hairy honeysuckle UNIV CHENGDU TRAD CN MEDICINE 2014-04-02 CN disclosed
CN-102924418-A Method for separating and purifying effective ingredients from fine felt hairy honeysuckle UNIV CHENGDU TRAD CN MEDICINE 2013-02-13 CN disclosed
CN-102879502-A Method for identifying lonicera similis hemsl high-quality medicinal materials UNIV CHENGDU TRAD CN MEDICINE 2013-01-16 CN disclosed
CN-102879502-A Method for identifying lonicera similis hemsl high-quality medicinal materials UNIV CHENGDU TRAD CN MEDICINE 2013-01-16 CN disclosed
US-20110144194-A1 CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES AXOGLIA THERAPEUTICS (LU) 2011-06-16 US disclosed
EP-2297127-A1 CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES AxoGlia Therapeutics S.A. (LU) 2011-03-23 EP disclosed
WO-2009130253-A1 CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES AXOGLIA THERAPEUTICS S.A. (LU) 2009-10-29 WO disclosed
EP-2112145-A1 Chromenone derivatives useful for the treatment of neurodegenerative diseases AxoGlia Therapeutics S.A. (LU) 2009-10-28 EP disclosed
US-20080287374-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR KABUSHIKI KAISHA YAKULT HONSHA (JP) 2008-11-20 US disclosed
US-20060135445-A1 Breast cancer-resistant protein inhibitor KABUSHIKI KAISHA YAKULT HONSHA (JP) 2006-06-22 US disclosed
EP-1591112-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR Kabushiki Kaisha Yakult Honsha (JP) 2005-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060135445-A1 Breast cancer-resistant protein inhibitor ABCC1, BCR, BRCA1 CYP1B1 815/4885PLG 4502/4885IP6K2 2224/4885
US-20110144194-A1 CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES PARK7, CDR2, SNCA CYP1B1 684/4885PLG 4569/4885IP6K2 3930/4885
US-20080287374-A1 BREAST CANCER-RESISTANT PROTEIN INHIBITOR ABCC1, BCR, BRCA1 CYP1B1 815/4885PLG 4502/4885IP6K2 2224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.