Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 4/20 | 0.54 |
| ▸ | CCND1 | P24385 | 4/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214721 | 0.79 | IGF1R (0.68) | IGF1REPHB4CDK2KDRAURKB | |
| SCHEMBL12185021 | 0.79 | ZAP70 (0.72) | IGF1RZAP70PRKD3LCKPRKCQ | |
| SCHEMBL6975169 | 0.77 | BRD4 (0.78) | BRD4IGF1RZAP70JAK2JAK3 | |
| SCHEMBL6981363 | 0.77 | PLK4 (0.67) | BRD4IGF1RZAP70AURKBAURKA | |
| SCHEMBL17526330 | 0.76 | BRD4 (1.00) | BRD4ALK | |
| SCHEMBL17526250 | 0.76 | BRD4 (1.00) | BRD4 | |
| SCHEMBL31163073 | 0.76 | BRD4 (1.00) | BRD4 | |
| SCHEMBL12184869 | 0.75 | JAK2 (0.66) | BRD4ZAP70KDRAURKBADORA3 | |
| SCHEMBL1927928 | 0.74 | IGF1R (0.61) | IGF1REPHB4RAB9AL3MBTL1KDR | |
| SCHEMBL6480192 | 0.74 | IGF1R (0.65) | IGF1REPHB4KDRAURKBPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |