Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480192 | 0.81 | IGF1R (0.65) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL21067672 | 0.81 | EPHB4 (1.00) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL14214593 | 0.80 | IGF1R (0.63) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL14214584 | 0.79 | IGF1R (0.66) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL14214534 | 0.79 | BRD4 (0.60) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL4946510 | 0.78 | EPHB4 (0.69) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL1927928 | 0.78 | IGF1R (0.61) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL13955883 | 0.78 | IGF1R (0.59) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL6481952 | 0.78 | EGFR (0.62) | IGF1REPHB4KDRAURKBPTK2 | |
| SCHEMBL14214750 | 0.77 | IGF1R (0.57) | IGF1REPHB4KDRAURKBPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |