Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 5/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380851 | 0.80 | SYK (0.49) | LCKKDRPTK2IGF1RSYK | |
| SCHEMBL14214678 | 0.76 | KDR (0.58) | LCKKDRMAPK14PTK2FGFR1 | |
| SCHEMBL14214725 | 0.75 | KDR (0.61) | LCKKDRMAPK14PTK2FGFR1 | |
| SCHEMBL14214691 | 0.72 | KDR (0.63) | LCKKDRMAPK14PTK2FGFR1 | |
| SCHEMBL14214727 | 0.69 | KDR (0.71) | LCKKDRMAPK14PTK2FGFR1 | |
| SCHEMBL14380880 | 0.67 | SYK (0.53) | LCKKDRPTK2IGF1RSYK | |
| SCHEMBL22864747 | 0.67 | MAP4K1 (0.58) | — | |
| SCHEMBL29651102 | 0.67 | MAP4K1 (0.58) | — | |
| SCHEMBL14380881 | 0.66 | SYK (0.51) | LCKKDRPTK2IGF1RSYK | |
| SCHEMBL14214630 | 0.65 | LCK (0.51) | LCKKDRMAPK14PTK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |