Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | LCK | P06239 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | IGF1R | P08069 | 3/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214678 | 0.89 | KDR (0.58) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214610 | 0.78 | PTK2 (0.54) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214618 | 0.76 | KDR (0.55) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL6478952 | 0.76 | KDR (0.74) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214675 | 0.75 | LCK (0.44) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL5478723 | 0.75 | MAPT (0.61) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214609 | 0.74 | KDR (0.87) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL6479183 | 0.73 | IGF1R (0.52) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214538 | 0.73 | KDR (0.52) | KDRLCKMAPK14IGF1RPTK2 | |
| SCHEMBL14214730 | 0.73 | KDR (0.82) | KDRLCKMAPK14IGF1RPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |