Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214617 | 0.82 | KDR (0.53) | NOD1SCN9AKCNH2SCN5APIK3CA | |
| SCHEMBL14214728 | 0.79 | MKNK1 (0.53) | SCN9APIK3CAMTORLCKKDR | |
| SCHEMBL14214626 | 0.78 | CDK1 (0.47) | PIK3CAMTORLCKKDRMAPK14 | |
| SCHEMBL14214621 | 0.78 | KDR (0.57) | PIK3CAMTORLCKKDRMAPK14 | |
| SCHEMBL16748475 | 0.78 | CHRNA7 (0.51) | PIK3CAMTORIDH1MEN1NPC1 | |
| SCHEMBL3244139 | 0.77 | PIK3CA (0.55) | SCN9AKCNH2SCN5APIK3CAMTOR | |
| SCHEMBL30568377 | 0.76 | SCN9A (0.61) | SCN9AKCNH2SCN5ACTSCABL1 | |
| SCHEMBL16748516 | 0.76 | CHRNA7 (0.46) | PIK3CAMTORIDH1MEN1NPC1 | |
| SCHEMBL14214682 | 0.75 | PIK3CA (0.45) | PIK3CAMTORLCKKDRMAPK14 | |
| SCHEMBL16748444 | 0.74 | BMI1 (0.49) | NOD1SCN9AKCNH2SCN5APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |