Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | MTOR | P42345 | 6/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214732 | 0.90 | SCN9A (0.59) | PIK3CAMTORSCN9APIK3CDPIK3CB | |
| SCHEMBL3244139 | 0.87 | PIK3CA (0.55) | PIK3CAMTORSCN9AAURKAJAK2 | |
| SCHEMBL14214617 | 0.85 | KDR (0.53) | PIK3CAMTORSCN9ALCKKDR | |
| SCHEMBL14380901 | 0.84 | MKNK1 (0.69) | MKNK1MKNK2MAPK8MAPK10AURKA | |
| SCHEMBL14214626 | 0.83 | CDK1 (0.47) | PIK3CAMTORAURKAAURKBJAK2 | |
| SCHEMBL14214627 | 0.83 | AURKA (0.48) | PIK3CAMTORMAPK8MAPK10AURKA | |
| SCHEMBL6479199 | 0.80 | PIK3CA (0.52) | PIK3CAMTORSCN9AAURKAJAK2 | |
| SCHEMBL14214724 | 0.79 | NOD1 (0.47) | PIK3CAMTORSCN9ALCKKDR | |
| SCHEMBL14214682 | 0.78 | PIK3CA (0.45) | PIK3CAMTORLCKKDRMAPK14 | |
| SCHEMBL14214621 | 0.76 | KDR (0.57) | PIK3CAMTORAURKBLCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |