Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214762 | 0.79 | AURKA (0.52) | AURKAJAK2AURKBTEKMAPK8 | |
| SCHEMBL2464720 | 0.69 | MAPK8 (0.50) | AURKAJAK2AURKBMAPK8MAPK10 | |
| SCHEMBL11115247 | 0.69 | KDM4E (0.64) | KDM4E | |
| SCHEMBL21724333 | 0.69 | MAPK8 (0.64) | AURKAJAK2AURKBMAPK8MAPK10 | |
| SCHEMBL13141033 | 0.69 | EGFR (0.39) | AURKAAURKBTEKFGFR2FGFR3 | |
| SCHEMBL14214605 | 0.67 | TEK (0.48) | AURKAAURKBTEKPTK2FGFR2 | |
| SCHEMBL6492448 | 0.67 | TEK (0.75) | TEKPTK2FGFR2FGFR3KDR | |
| SCHEMBL17630275 | 0.66 | AURKA (0.54) | AURKAJAK2AURKBMAPK8MAPK10 | |
| SCHEMBL17815613 | 0.66 | CA12 (0.60) | AURKAJAK2AURKBMAPK8MAPK10 | |
| SCHEMBL4983171 | 0.66 | MAPK8 (0.46) | AURKAMAPK8MAPK10CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |