Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214760 | 0.79 | AURKA (0.44) | AURKAAURKBMAPK8MAPK10CDK4 | |
| SCHEMBL17630275 | 0.78 | AURKA (0.54) | AURKAAURKBMAPK8MAPK10CDK4 | |
| SCHEMBL2464720 | 0.76 | MAPK8 (0.50) | AURKAAURKBMAPK8MAPK10CDK2 | |
| SCHEMBL14214603 | 0.76 | SYK (0.48) | AURKACDK4CDK2GSK3BFGFR2 | |
| SCHEMBL21724333 | 0.76 | MAPK8 (0.64) | AURKAAURKBMAPK8MAPK10CDK4 | |
| SCHEMBL14214634 | 0.75 | FGFR3 (0.67) | AURKAAURKBCDK2JAK2FGFR2 | |
| SCHEMBL13141028 | 0.75 | SYK (0.48) | CDK4CDK2GSK3BFGFR2FGFR3 | |
| SCHEMBL4107280 | 0.74 | MAPK8 (0.70) | AURKAAURKBMAPK8MAPK10CDK4 | |
| SCHEMBL581005 | 0.74 | FGFR3 (0.43) | FGFR2FGFR3TEK | |
| SCHEMBL6479711 | 0.72 | TEK (0.73) | AURKBCDK2JAK2FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |