Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14215745 | 0.90 | NR1H4 (0.40) | NR1H4MEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL14215779 | 0.86 | ABL1 (0.36) | NR1H4ABL1 | |
| SCHEMBL14215780 | 0.83 | NR1H4 (0.48) | NR1H4L3MBTL1 | |
| SCHEMBL14215804 | 0.78 | NR1H4 (0.41) | NR1H4ABL1MEN1KMT2A | |
| SCHEMBL2003064 | 0.76 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL14215781 | 0.76 | MAPT (0.39) | NR1H4CYP11B1CYP11B2GAA | |
| SCHEMBL14215701 | 0.74 | ALDH1A1 (0.37) | NR1H4 | |
| SCHEMBL14215880 | 0.72 | NR1H4 (0.58) | NR1H4 | |
| SCHEMBL4332220 | 0.71 | NR1H4 (0.46) | NR1H4MEN1KMT2AESR1THRA | |
| SCHEMBL14215700 | 0.71 | NR1H4 (0.43) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |