Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.58 |
| ▸ | SRC | P12931 | 8/20 | 0.58 |
| ▸ | CDK2 | P24941 | 9/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216145 | 0.89 | SYK (0.67) | SYKZAP70SRCCDK2CDK9 | |
| SCHEMBL14216021 | 0.87 | SYK (0.64) | SYKZAP70SRCCDK2CDK9 | |
| SCHEMBL14216038 | 0.82 | SYK (0.67) | SYKZAP70SRCCDK2CDK9 | |
| SCHEMBL14216052 | 0.82 | SYK (0.77) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216171 | 0.80 | SYK (0.56) | SYKZAP70SRCCDK2CDK9 | |
| SCHEMBL14216049 | 0.80 | SYK (0.76) | SYKZAP70SRCCDK2CDK9 | |
| SCHEMBL14216138 | 0.79 | SYK (0.63) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216155 | 0.79 | SYK (0.65) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14215970 | 0.79 | SYK (0.62) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216309 | 0.78 | SYK (0.67) | SYKZAP70SRCCDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |