Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.72 |
| ▸ | CDK2 | P24941 | 8/20 | 0.72 |
| ▸ | SYK | P43405 | 8/20 | 0.72 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.72 |
| ▸ | CDK4 | P11802 | 5/20 | 0.65 |
| ▸ | ABL1 | P00519 | 4/20 | 0.60 |
| ▸ | BCR | P11274 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PRKACB | P22694 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216223 | 0.89 | CDK2 (0.60) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216222 | 0.88 | CDK2 (0.79) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216081 | 0.86 | ZAP70 (0.88) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL4391357 | 0.86 | CDK2 (0.68) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216159 | 0.85 | CDK2 (0.64) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14378961 | 0.85 | CDK2 (0.74) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216006 | 0.85 | SYK (0.74) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216079 | 0.85 | CDK2 (0.67) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216065 | 0.84 | SYK (0.69) | SRCCDK2SYKZAP70CDK4 | |
| SCHEMBL14216069 | 0.84 | CDK2 (0.65) | SRCCDK2SYKZAP70CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |